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Article

Genetic susceptibility and late bone outcomes in childhood acute lymphoblastic leukemia survivors.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 22 Mar 2024

Geneviève Nadeau, Mojgan Yazdanpanah, Nahid Yazdanpanah, Vincenzo Forgetta, Simon Girard, Daniel Sinnett, Maja Krajinovic, Nathalie Alos, Despoina Manousaki

Abstract excerpt

Childhood acute lymphoblastic leukemia (cALL) survivors are at increased risk for bone comorbidities, but accurate screening tools for such comorbidities are limited. Polygenic scores (PGS) could stratify cALL survivors for risk of long-term adverse bone outcomes. We evaluated 214 (51% female) cALL survivors from the Prévenir les Effets TArdifs de la LEucémie study (median age 21 yr). Bone mineral density (BMD)...

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PMID: 38477791
DOI: 10.1093/jbmr/zjad013

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