Article

Mechanisms of dexamethasone-induced bone toxicity in developing bone: a single-cell perspective

2025-01-15

Abstract excerpt

<h4> Abstract </h4> Glucocorticoids, such as dexamethasone, are essential for treating severe childhood conditions, including cancer, organ transplantation, and inflammatory disorders. However, their long-term use can impair bone development, posing risks to pediatric bone health, which is vital for lifelong skeletal integrity. A mechanistic insight on how glucocorticoids negatively impact bone could improve dec...

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Literature Corpus work: fec21e62-8c4f-5c19-8d63-ef58a9075132
DOI: 10.1101/2025.01.13.632523

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