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Inherited genetic variants associated with glucocorticoid sensitivity in leukaemia cells.

Journal of cellular and molecular medicine - 1 Nov 2020

Shinohara Tamao, Urayama Kevin Y, Watanabe Atsushi, Akahane Koshi, Goi Kumiko, Huang Meixian, Kagami Keiko, Abe Masako, Sugita Kanji, Okada Yukinori, Goto Hiroaki, Minegishi Masayoshi, Iwamoto Shotaro, Inukai Takeshi

Abstract excerpt

Identification of genetic variants associated with glucocorticoids (GC) sensitivity of leukaemia cells may provide insight into potential drug targets and tailored therapy. In the present study, within 72 leukaemic cell lines derived from Japanese patients with B-cell precursor acute lymphoblastic leukaemia (ALL), we conducted genome-wide genotyping of single nucleotide polymorphisms (SNP) and attempted to...

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Dexamethasone
Drug Screening Assays, Antitumor
Gene Expression Regulation, Leukemic
Glucocorticoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inhibitory Concentration 50

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Receptors, Glucocorticoid

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Identifiers

PMID: 33002292
DOI: 10.1111/jcmm.15882
PMCID: PMC7701530

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