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Article

Genetics of pleiotropic effects of dexamethasone.

Pharmacogenetics and genomics - 1 Aug 2017

Ramsey Laura B, Pounds Stan, Cheng Cheng, Cao Xueyuan, Yang Wenjian, Smith Colton, Karol Seth E, Liu Chengcheng, Panetta John C, Inaba Hiroto, Rubnitz Jeffrey E, Metzger Monika L, Ribeiro Raul C, Sandlund John T, Jeha Sima, Pui Ching-Hon, Evans William E, Relling Mary V

Abstract excerpt

OBJECTIVES: Glucocorticoids such as dexamethasone have pleiotropic effects, including desired antileukemic, anti-inflammatory, or immunosuppressive effects, and undesired metabolic or toxic effects. The most serious adverse effects of dexamethasone among patients with acute lymphoblastic leukemia are osteonecrosis and thrombosis. To identify inherited genomic variation involved in these severe adverse effects, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28628558
DOI: 10.1097/FPC.0000000000000293
PMCID: PMC5523978

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