Article
MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.
Nature communications - 11 Jun 2020
Huang Jen-Wei, Acharya Ananya, Taglialatela Angelo, Nambiar Tarun S, Cuella-Martin Raquel, Leuzzi Giuseppe, Hayward Samuel B, Joseph Sarah A, Brunette Gregory J, Anand Roopesh, Soni Rajesh K, Clark Nathan L, Bernstein Kara A, Cejka Petr, Ciccia Alberto
Abstract excerpt
Homologous recombination (HR) mediates the error-free repair of DNA double-strand breaks to maintain genomic stability. Here we characterize C17orf53/MCM8IP, an OB-fold containing protein that binds ssDNA, as a DNA repair factor involved in HR. MCM8IP-deficient cells exhibit HR defects, especially in long-tract gene conversion, occurring downstream of RAD51 loading, consistent with a role for MCM8IP in...
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