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Article

Trim33 masks a non-transcriptional function of E2f4 in replication fork progression.

Nature communications - 23 Aug 2023

Rousseau Vanessa, Einig Elias, Jin Chao, Horn Julia, Riebold Mathias, Poth Tanja, Jarboui Mohamed-Ali, Flentje Michael, Popov Nikita

Abstract excerpt

Replicative stress promotes genomic instability and tumorigenesis but also presents an effective therapeutic endpoint, rationalizing detailed analysis of pathways that control DNA replication. We show here that the transcription factor E2f4 recruits the DNA helicase Recql to facilitate progression of DNA replication forks upon drug- or oncogene-induced replicative stress. In unperturbed cells, the Trim33...

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Identifiers

PMID: 37612308
DOI: 10.1038/s41467-023-40847-0
PMCID: PMC10447549

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