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Article

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells.

PloS one - 1 Jan 2016

Chu Chia, Bottaro Donald P, Betenbaugh Michael J, Shiloach Joseph

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a complex cancer progression that can boost the metastatic potential of transformed cells by inducing migration, loss of cell adhesion, and promoting proliferation under anchorage-independent conditions. A DNA microarray analysis was performed comparing parental anchorage-dependent MDCK cells and anchorage-independent MDCK cells that were engineered to express human...

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Share to Autocrine Communication
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Madin Darby Canine Kidney Cells

Share to Matrix Metalloproteinase 1

Share to Proto-Oncogene Proteins c-met

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Source

Open in PubMed Open full text

Identifiers

PMID: 26848584
DOI: 10.1371/journal.pone.0148075
PMCID: PMC4743853

Genes

MET
HGF
MMP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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