Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity.

PloS one - 1 Jan 2012

Lawson Erica L, Mills David R, Brilliant Kate E, Hixson Douglas C

Abstract excerpt

CEACAM1 is a multifunctional Ig-like cell adhesion molecule expressed by epithelial cells in many organs. CEACAM1-4L and CEACAM1-4S, two isoforms produced by differential splicing, are predominant in rat liver. Previous work has shown that downregulation of both isoforms occurs in rat hepatocellular carcinomas. Here, we have isolated an anchorage dependent clone, designated 253T-NT that does not express...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Carcinoma, Hepatocellular
Share to Cell Adhesion Molecules

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Size

Share to Liver Neoplasms

Share to Protein Isoforms

Share to Protein Transport

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 22235309
DOI: 10.1371/journal.pone.0029606
PMCID: PMC3250453

Genes

CEACAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transmembrane domain of CEACAM1-4S is a determinant of anchorage independent growth and tumorigenicity.PMID 22235309Read ↗

On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human MalignanciesSemantic proximity Read ↗

β4 Integrin Is a Transforming Molecule that Unleashes Met Tyrosine Kinase TumorigenesisSemantic proximity Read ↗

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells.Semantic proximity Read ↗

Altered splicing of CEACAM1 in breast cancer: Identification of regulatory sequences that control splicing of CEACAM1 into long or short cytoplasmic domain isoformsSemantic proximity Read ↗

Mechanism and function of CEACAM1 splice isoformsSemantic proximity Read ↗

Isolation of a novel mouse gene, mSVS-1/SUSD2, reversing tumorigenic phenotypes of cancer cells in vitro.Semantic proximity Read ↗

Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genesSemantic proximity Read ↗

Ly6 family member C4.4A binds laminins 1 and 5, associates with galectin-3 and supports cell migration.Semantic proximity Read ↗

Deregulation of the CEACAM Expression Pattern Causes Undifferentiated Cell Growth in Human Lung Adenocarcinoma CellsSemantic proximity Read ↗

Pituitary Tumor-Derived Fibroblast Growth Factor Receptor 4 Isoform Disrupts Neural Cell-Adhesion Molecule/N-Cadherin Signaling to Diminish Cell Adhesiveness: A Mechanism Underlying Pituitary NeoplasiaSemantic proximity Read ↗

In vivo survivors of transformed mouse ovarian surface epithelial cells display diverse phenotypes for gene expression and tumorigenicity.Semantic proximity Read ↗

Activation of the Met Receptor by Cell Attachment Induces and Sustains Hepatocellular Carcinomas in Transgenic MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.