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Article

β4 Integrin Is a Transforming Molecule that Unleashes Met Tyrosine Kinase Tumorigenesis

1 Dec 2005

Abstract excerpt

Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogenic conversion. beta4 integrin stimulates proliferation and survival of epithelial cells and is...

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PMID: 16322210
DOI: 10.1158/0008-5472.can-05-2827

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