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Article

Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.

Proceedings of the National Academy of Sciences of the United States of America - 24 May 1994

Rong S, Segal S, Anver M, Resau J H, Vande Woude G F

Abstract excerpt

The met protooncogene product, Met, is the tyrosine kinase growth factor receptor for hepatocyte growth factor/scatter factor (HGF/SF). NIH 3T3 cells express HGF/SF endogenously and become tumorigenic in nude mice via an autocrine mechanism when murine Met is expressed ectopically (Metmu cells) o...

Topics

3T3 Cells
Animals
Cell Movement
Cell Transformation, Neoplastic
Collagenases
Hepatocyte Growth Factor
Humans
Mice
Mice, Nude
Neoplasm Invasiveness
Neoplasm Metastasis
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins

Proto-Oncogene Proteins c-met

Receptor Protein-Tyrosine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 8197126
DOI: 10.1073/pnas.91.11.4731
PMCID: PMC43862

Genes

HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8197126-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation.PMID 8197126Read ↗

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The roles of hepatocyte growth factor/scatter factor and met receptor in human cancers (Review).Semantic proximity Read ↗

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MET: a critical player in tumorigenesis and therapeutic target.Semantic proximity Read ↗

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