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Article

MET: a critical player in tumorigenesis and therapeutic target.

Cold Spring Harbor perspectives in biology - 1 Jul 2013

Graveel Carrie R, Tolbert David, Vande Woude George F

Abstract excerpt

Since its discovery more than 25 years ago, numerous studies have established that the MET receptor is unique among tyrosine kinases. Signaling through MET is necessary for normal development and for the progression of a wide range of human cancers. MET activation has been shown to drive numerous signaling pathways; however, it is not clear how MET signaling mediates diverse cellular responses such as motility,...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Hepatocyte Growth Factor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to Proto-Oncogene Proteins c-met

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Source

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Identifiers

PMID: 23818496
DOI: 10.1101/cshperspect.a009209
PMCID: PMC3685898

Genes

MET
HGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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