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Article

MMP7 Is Required to Mediate Cell Invasion and Tumor Formation upon Plakophilin3 Loss

13 Apr 2015

Abstract excerpt

Plakophilin3 (PKP3) loss results in increased transformation in multiple cell lines in vitro and increased tumor formation in vivo. A microarray analysis performed in the PKP3 knockdown clones, identified an inflammation associated gene signature in cell lines derived from stratified epithelia as opposed to cell lines derived from simple epithelia. However, in contrast to the inflammation associated gene...

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PMID: 25875355
DOI: 10.1371/journal.pone.0123979

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