Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Up‐regulation of SPINT 2/ HAI ‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesion

28 Nov 2018

Abstract excerpt

Abstract The role of tumour microenvironment in neoplasm initiation and malignant evolution has been increasingly recognized. However, the bone marrow mesenchymal stromal cell (BMMSC) contribution to disease progression remains poorly explored. We previously reported that the expression of serine protease inhibitor kunitz‐type2 (SPINT2/HAI‐2), an inhibitor of hepatocyte growth factor (HGF) activation, is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Epigenetics and DNA Methylation
Share to Hematopoietic Stem Cell Transplantation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30484958
DOI: 10.1111/jcmm.14066

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Up‐regulation of SPINT 2/ HAI ‐2 by Azacytidine in bone marrow mesenchymal stromal cells affects leukemic stem cell survival and adhesionPMID 30484958Read ↗

Direct modulation of the bone marrow mesenchymal stromal cell compartment by azacitidine enhances healthy hematopoiesisSemantic proximity Read ↗

HDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?Semantic proximity Read ↗

Functional inhibition of mesenchymal stromal cells in acute myeloid leukemia.Semantic proximity Read ↗

Chromatin modifier Hmga2 promotes adult hematopoietic stem cell function and blood regeneration in stress conditionsSemantic proximity Read ↗

Fibroblast Growth Factor 2 Regulates High Mobility Group A2 Expression in Human Bone Marrow‐Derived Mesenchymal Stem CellsSemantic proximity Read ↗

Bone marrow mesenchymal/fibroblastic stromal cells induce a distinctive EMT-like phenotype in AML cells.Semantic proximity Read ↗

Epigenetic features of human mesenchymal stem cells determine their permissiveness for induction of relevant transcriptional changes by SYT-SSX1.Semantic proximity Read ↗

High expression of ABCG2 induced by EZH2 disruption has pivotal roles in MDS pathogenesis.Semantic proximity Read ↗

A Concerted HIF-1α/MT1-MMP Signalling Axis Regulates the Expression of the 3BP2 Adaptor Protein in Hypoxic Mesenchymal Stromal CellsSemantic proximity Read ↗

Adhesion Molecules Involved in Stem Cell Niche Retention During Normal Haematopoiesis and in Acute Myeloid LeukaemiaSemantic proximity Read ↗

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor β signalingSemantic proximity Read ↗

Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.