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Article

α2-6–Linked Sialic Acids on N-Glycans Modulate Carcinoma Differentiation <i>In vivo</i>

15 Jan 2008

Abstract excerpt

Sialic acids on vertebrate cell surfaces mediate many biological roles. Altered expression of certain sialic acid types or their linkages can have prognostic significance in human cancer. A classic but unexplained example is enhanced alpha2-6-sialylation on N-glycans resulting from overexpression of the Golgi enzyme beta-galactoside:alpha2-6-sialyltransferase (ST6Gal-I). Previous data supporting a role for the...

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PMID: 18199532
DOI: 10.1158/0008-5472.can-07-1340

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