HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

doi:10.1016/j.mce.2016.01.027

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.

Molecular and cellular endocrinology - 15 Jul 2016

Zhou Yuedan, Oskolkov Nikolay, Shcherbina Liliya, Ratti Joyce, Kock Kian-Hong, Su Jing, Martin Brian, Oskolkova Malin Zackrisson, Göransson Olga, Bacon Julie, Li Weimin, Bucciarelli Saskia, Cilio Corrado, Brazma Alvis, Thatcher Bradley, Rung Johan, Wierup Nils, Renström Erik, Groop Leif, Hansson Ola

Abstract excerpt

The intronic SNP rs7903146 in the T-cell factor 7-like 2 gene (TCF7L2) is the common genetic variant most highly associated with Type 2 diabetes known to date. The risk T-allele is located in an open chromatin region specific to human pancreatic islets of Langerhans, thereby accessible for binding of regulatory proteins. The risk T-allele locus exhibits stronger enhancer activity compared to the non-risk...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to HCT116 Cells

Share to HEK293 Cells

Share to HMGB1 Protein

Share to Islets of Langerhans

Share to Reproducibility of Results

Share to Transcription Factor 7-Like 2 Protein

Source

Open in PubMed

Identifiers

PMID: 26845344
DOI: 10.1016/j.mce.2016.01.027

Genes

HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HMGB1 binds to the rs7903146 locus in TCF7L2 in human pancreatic islets.PMID 26845344Read ↗

A map of open chromatin in human pancreatic islets.Semantic proximity Read ↗

Functional analysis of TCF7L2 genetic variants associated with type 2 diabetes.Semantic proximity Read ↗

A Common Type 2 Diabetes Risk Variant Potentiates Activity of an Evolutionarily Conserved Islet Stretch Enhancer and Increases C2CD4A and C2CD4B Expression.Semantic proximity Read ↗

Expression and functional assessment of candidate type 2 diabetes susceptibility genes identify four new genes contributing to human insulin secretion.Semantic proximity Read ↗

Transcription factor TCF7L2 genetic study in the French population: expression in human beta-cells and adipose tissue and strong association with type 2 diabetes.Semantic proximity Read ↗

The TCF7L2 locus and type 1 diabetes.Semantic proximity Read ↗

Genetic and epigenetic regulation of gene expression in pancreatic isletsSemantic proximity Read ↗

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk.Semantic proximity Read ↗

The RNA-binding profile of the splicing factor SRSF6 in immortalized human pancreatic β-cellsSemantic proximity Read ↗

The role of transcription factor 7‐like 2 in metabolic disordersSemantic proximity Read ↗

The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA.Semantic proximity Read ↗

In vitro scan for enhancers at the TCF7L2 locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.