Article
The T1D-associated lncRNA Lnc13 modulates human pancreatic β cell inflammation by allele-specific stabilization of STAT1 mRNA.
Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2020
Gonzalez-Moro Itziar, Olazagoitia-Garmendia Ane, Colli Maikel L, Cobo-Vuilleumier Nadia, Postler Thomas S, Marselli Lorella, Marchetti Piero, Ghosh Sankar, Gauthier Benoit R, Eizirik Decio L, Castellanos-Rubio Ainara, Santin Izortze
Abstract excerpt
The vast majority of type 1 diabetes (T1D) genetic association signals lie in noncoding regions of the human genome. Many have been predicted to affect the expression and secondary structure of long noncoding RNAs (lncRNAs), but the contribution of these lncRNAs to the pathogenesis of T1D remains to be clarified. Here, we performed a complete functional characterization of a lncRNA that harbors a single...
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