Article

Genetic and epigenetic regulation of gene expression in pancreatic islets

2016-01-01

Abstract excerpt

T2D is a complex disease with evidence of a strong genetic basis. Studies of the human pancreatic islets have provided valuable insight into the islet regulatory landscape and identified enrichment of T2D-associated variants in islet enhancers. The relationship between cis-regulatory variation and changes in gene expression, however, remains unclear. This question is challenging to address in human, as it calls fo...

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Literature Corpus work: 0d58e273-f992-511a-ba51-3079915a486e
DOI: 10.25560/67554

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