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Article

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 May 2026

Wang Xiaoyang, Geng Hui, Yao Zhengyan, Jiang Yuan, Chen Can, Lu Zequn, Tian Shuangshuang, Zhang Ming, Liu Ruiyan, Feng Chenxi, Li Bin, Miao Xiaoping, Tian Jianbo, Zhang Shaokai, Zhu Ying

Abstract excerpt

Pancreatic cancer is one of the most lethal malignancies. Genome-wide association studies (GWAS) identify multiple susceptibility loci, but most map to noncoding regions, leaving variant-to-gene links unresolved. In this study, a genome-wide regulatory map is constructed using expression quantitative trait loci (eQTL) analysis of 482 pancreatic tissues, and integrated with a GWAS meta-analysis to prioritize...

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Share to Gene Expression Regulation, Neoplastic
Share to Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Pancreatic Neoplasms

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 41824785
DOI: 10.1002/advs.202517184
PMCID: PMC13205582

Genes

ST7L
ZNF263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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