Article
Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jan 2016
Jiang Fangfang, Lu Falong, Li Peixue, Liu Wei, Zhao Lu, Wang Qifu, Cao Xiaofeng, Zhang Lei, Zhang Yong Q
Abstract excerpt
Fragile X syndrome (FraX), the most common form of inherited mental retardation, is caused by the absence of the evolutionally conserved fragile X mental retardation protein (FMRP). While neuronal functions of FMRP have been intensively studied for the last two decades, its role in non-neuronal cells remains poorly understood. Piwi, a key component of the Piwi-interacting RNA (piRNA) pathway, plays an essential...
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