Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2013

Darricarrère Nicole, Liu Na, Watanabe Toshiaki, Lin Haifan

Abstract excerpt

The Piwi protein subfamily is essential for Piwi-interacting RNA (piRNA) biogenesis, transposon silencing, and germ-line development, all of which have been proposed to require Piwi endonuclease activity, as validated for two cytoplasmic Piwi proteins in mice. However, recent evidence has led to questioning of the generality of this mechanism for the Piwi members that reside in the nucleus. Drosophila offers a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Argonaute Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Transposable Elements

Share to Drosophila melanogaster

Share to Drosophila Proteins

Share to Oogenesis

Share to Protein Stability

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 23297219
DOI: 10.1073/pnas.1213283110
PMCID: PMC3557079

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Function of Piwi, a nuclear Piwi/Argonaute protein, is independent of its slicer activity.PMID 23297219Read ↗

Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.Semantic proximity Read ↗

piRNA pathway and the potential processing site, the nuage, in the Drosophila germline.Semantic proximity Read ↗

Biology of PIWI-interacting RNAs: new insights into biogenesis and function inside and outside of germlines.Semantic proximity Read ↗

PIWI proteins and PIWI-interacting RNAs in the soma.Semantic proximity Read ↗

Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary.Semantic proximity Read ↗

piRNAs and their involvement in male germline development in mice.Semantic proximity Read ↗

Slicing and Binding by Ago3 or Aub Trigger Piwi-Bound piRNA Production by Distinct Mechanisms.Semantic proximity Read ↗

A genetic toolkit for studying transposon control in the <i>Drosophila melanogaster</i> ovarySemantic proximity Read ↗

Somatic function of the Argonaute protein Aubergine is essential for neuromuscular development and function in <i>Drosophila</i>Semantic proximity Read ↗

Pinpointing the expression of piRNAs and function of the PIWI protein subfamily during spermatogenesis in the mouse.Semantic proximity Read ↗

piRNAs--the ancient hunters of genome invaders.Semantic proximity Read ↗

<i>putzig</i> safeguards genome integrity by contributing to the Piwi-mediated repression of transposon activity in the female germline of <i>Drosophila</i> in a two-tiered fashionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.