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Article

Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P.

Disease models & mechanisms - 1 Jan 2010

Coffee R Lane, Tessier Charles R, Woodruff Elvin A, Broadie Kendal

Abstract excerpt

Fragile X syndrome (FXS), resulting solely from the loss of function of the human fragile X mental retardation 1 (hFMR1) gene, is the most common heritable cause of mental retardation and autism disorders, with syndromic defects also in non-neuronal tissues. In addition, the human genome encodes two closely related hFMR1 paralogs: hFXR1 and hFXR2. The Drosophila genome, by contrast, encodes a single dFMR1 gene...

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Source

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Identifiers

PMID: 20442204
DOI: 10.1242/dmm.004598
PMCID: PMC2898537

Genes

FMR1
FXR1
FXR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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