Article
A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.
Cell - 8 May 2014
Alpatov Roman, Lesch Bluma J, Nakamoto-Kinoshita Mika, Blanco Andres, Chen Shuzhen, Stützer Alexandra, Armache Karim J, Simon Matthew D, Xu Chao, Ali Muzaffar, Murn Jernej, Prisic Sladjana, Kutateladze Tatiana G, Vakoc Christopher R, Min Jinrong, Kingston Robert E, Fischle Wolfgang, Warren Stephen T, Page David C, Shi Yang
Abstract excerpt
Fragile X syndrome, a common form of inherited intellectual disability, is caused by loss of the fragile X mental retardation protein FMRP. FMRP is present predominantly in the cytoplasm, where it regulates translation of proteins that are important for synaptic function. We identify FMRP as a chromatin-binding protein that functions in the DNA damage response (DDR). Specifically, we show that FMRP binds...
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