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AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination

11 Dec 2009

Abstract excerpt

To initiate class switch recombination (CSR) activation-induced cytidine deaminase (AID) induces staggered nick cleavage in the S region, which lies 5' to each Ig constant region gene and is rich in palindromic sequences. Topoisomerase 1 (Top1) controls the supercoiling of DNA by nicking, rotating, and religating one strand of DNA. Curiously, Top1 reduction or AID overexpression causes the genomic instability....

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PMID: 20018730
DOI: 10.1073/pnas.0911879106

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