Alteration of melanoma cell phenotype following in vitro culturing and exposure to cytostatic agents.

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Article

Alteration of melanoma cell phenotype following in vitro culturing and exposure to cytostatic agents.

Anticancer research - 1 Jan 2000

Engel E, Kleeberg U R, Dietel M, Bröcker E B, Carrel S

Abstract excerpt

Pleiotropic drug resistance is supposed to be associated with a particular tumor cell phenotype, defined by certain plasma membrane glycolipids. Therefore we wondered how far chemosensitivity in vitro correlates with phenotypic characteristics of melanoma cells, which are known to be highly refractory to cytocidal agents. 13 monolayer cell cultures of metastatic melanoma derived from 9 patients were tested with...

Topics

Antibodies, Monoclonal
Antigens, Neoplasm
Antineoplastic Agents
Carboplatin
Cisplatin
DNA, Neoplasm
Dacarbazine
Flow Cytometry
HLA Antigens
Humans
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Melanoma-Specific Antigens

Neoplasm Metastasis

Neoplasm Proteins

Organoplatinum Compounds

Phenotype

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 2683998

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2683998-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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