Article
Enhanced expression of HLA-DR antigens by the human melanoma cell line CaCL 73-36 upon induction of a less differentiated phenotype with bromodeoxyuridine.
Anticancer research - 1 Jan 2000
Kawakubo Y, Liao S K
Abstract excerpt
The effects of bromodeoxyuridine (BUdr) on the in vitro growth, morphology and expression of HLA-DR antigens in the human melanoma line CaCL 73-36 were studied. Treatment of melanoma cells with BUdr resulted in an inhibition of growth with 30-35% reduction in saturation density at 2 micrograms/ml and 50-54% reduction at 4 micrograms/ml. BUdr-treated melanoma cells showed marked morphological changes including...
Topics
- Bromodeoxyuridine
- Cell Line
- Electrophoresis, Polyacrylamide Gel
- HLA-D Antigens
- HLA-DR Antigens
- Humans
- Melanoma
- Phenotype
- Thymidine