Generation of adhesive tumor variants: chromosomal changes, reduction in malignancy and increased expression of a distinct membrane glycoprotein.

doi:10.1007/BF01784379

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Article

Generation of adhesive tumor variants: chromosomal changes, reduction in malignancy and increased expression of a distinct membrane glycoprotein.

Clinical & experimental metastasis - 1 Jan 2000

Pflüger E, Lang E, Benke R, Heckl-Ostreicher B, Altevogt P, Schirrmacher V

Abstract excerpt

Tumor cell variants which grow adherent to a plastic surface could be isolated in a reproducible way from the high metastatic tumor cell line ESb which grows in a suspension culture. This occurred when starting selection from the uncloned parental line as well as from a freshly derived non-adhesive subclone. The variants showed changes in their karyotype. These were quantitative (tetraploidization) and...

Topics

Animals
Antibodies, Monoclonal
Cell Adhesion
Cell Line
Chromosomes
Clone Cells
Fluorescent Antibody Technique
Karyotyping
Membrane Glycoproteins
Mice
Mice, Inbred DBA

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

Neoplasm Proteins

Neoplasm Transplantation

Neoplasms, Experimental

Phenotype

Rats

Rats, Inbred Strains

Source

Open in PubMed

Identifiers

PMID: 3044658
DOI: 10.1007/BF01784379

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3044658-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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