Human melanoma cells with high susceptibility to cell-mediated lysis can be identified on the basis of ICAM-1 phenotype, VLA profile and invasive ability.

doi:10.1002/ijc.2910460330

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Article

Human melanoma cells with high susceptibility to cell-mediated lysis can be identified on the basis of ICAM-1 phenotype, VLA profile and invasive ability.

International journal of cancer - 15 Sept 1990

Anichini A, Mortarini R, Supino R, Parmiani G

Abstract excerpt

Marked heterogeneity for susceptibility to lysis by autologous CTL clones and allogeneic IL-2-activated CD3- and CD3+ lymphocytes was found among 19 clones isolated from a human metastatic melanoma (Me665/2). A subset of 5 clones with the highest susceptibility to lysis had increased ICAM-1 antigen expression. Phenotype analysis for the presence of extracellular matrix receptors in the beta 1- and beta 3-integrin...

Topics

Antibodies, Monoclonal
Cell Adhesion Molecules
Cell Survival
Clone Cells
Cytotoxicity, Immunologic
Flow Cytometry
Humans
Integrins
Intercellular Adhesion Molecule-1
Interleukin-2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocyte Activation

Melanoma

Neoplasm Invasiveness

Phenotype

Receptors, Very Late Antigen

T-Lymphocytes, Cytotoxic

Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 1975567
DOI: 10.1002/ijc.2910460330

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1975567-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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