Article
In vitro phenotypic alteration of human melanoma cells induced by differentiating agents: heterogeneous effects on cellular growth and morphology, enzymatic activity, and antigenic expression.
Pigment cell research - 1 Nov 1990
Takahashi H, Parsons P G
Abstract excerpt
Sodium butyrate (butyrate), 5-azacytidine (5Aza-C), dimethyl sulfoxide (DMSO), and dimethyl formamide (DMF) were applied to a human melanoma cell line for the purpose of inducing pigmentation and terminal differentiation. The results are summarized as follows: 1) butyrate, DMSO, and DMF had a strong cytostatic effect, arresting cells in the G1 phase of the cycle; 2) butyrate caused a morphological change to...
Topics
- Antigens, Neoplasm
- Azacitidine
- Butyrates
- Butyric Acid
- Cell Cycle
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Survival
- Dimethyl Sulfoxide
- Dimethylformamide