Article
In vitro modulation of the metastatic phenotype. I. Analysis of differentiation forms of the B16 melanoma expressing Met-72 determinants and metastatic activity.
Clinical & experimental metastasis - 1 Jan 2000
Xiang J H, Kimura A K
Abstract excerpt
In vitro cultures of a highly metastatic B16 melanoma clone (BL6-10) were found to undergo dramatic changes in morphology and differentiation upon transfer to another culture medium. Specifically, BL6-10 melanoma cells which had been originally selected and adapted for growth in Eagles' Hanks' amino acid supplemented media with 10 per cent newborn calf serum were amelanotic and epitheliod in shape. When these...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Membrane
- Culture Media
- Epitopes
- Female
- Flow Cytometry
- Lung Neoplasms