Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.

Scientific reports - 2 Feb 2016

Fukuda Shinji, Nishida-Fukuda Hisayo, Nanba Daisuke, Nakashiro Koh-ichi, Nakayama Hironao, Kubota Hiroyuki, Higashiyama Shigeki

Abstract excerpt

Epithelial cell plasticity is controlled by extracellular cues, but the underlying mechanisms remain to be fully understood. Epidermal growth factor (EGF) and amphiregulin (AREG) are high- and low-affinity ligands for EGF receptor (EGFR), respectively. EGFR signaling is known to promote epithelial-mesenchymal transition (EMT) by the activation of ERK and the induction of an EMT transcription factor, ZEB1. Here,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermal Growth Factor
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial-Mesenchymal Transition

Share to ErbB Receptors

Share to Ligands

Share to Mammary Glands, Human

Share to MAP Kinase Signaling System

Share to Transforming Growth Factor beta

Source

Open in PubMed Open full text

Identifiers

PMID: 26831618
DOI: 10.1038/srep20209
PMCID: PMC4735799

Genes

EGFR
AREG
EGF
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.PMID 26831618Read ↗

Cell and molecular biology of epidermal growth factor receptor.Semantic proximity Read ↗

Distinct Effects of EGFR Ligands on Human Mammary Epithelial Cell DifferentiationSemantic proximity Read ↗

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression HeterogeneitySemantic proximity Read ↗

EGF controls the in vivo developmental potential of a mammary epithelial cell line possessing progenitor properties.Semantic proximity Read ↗

Transgenic and knock-out mice for deciphering the roles of EGFR ligands.Semantic proximity Read ↗

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptorSemantic proximity Read ↗

An integrated mechanistic and data-driven computational model predicts cell responses to high- and low-affinity EGFR ligandsSemantic proximity Read ↗

Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.Semantic proximity Read ↗

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.Semantic proximity Read ↗

EGR1 and the ERK‐ERF axis drive mammary cell migration in response to EGFSemantic proximity Read ↗

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.Semantic proximity Read ↗

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.