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Article

Distinct Effects of EGFR Ligands on Human Mammary Epithelial Cell Differentiation

4 Oct 2013

Abstract excerpt

Based on gene expression patterns, breast cancers can be divided into subtypes that closely resemble various developmental stages of normal mammary epithelial cells (MECs). Thus, understanding molecular mechanisms of MEC development is expected to provide critical insights into initiation and progression of breast cancer. Epidermal growth factor receptor (EGFR) and its ligands play essential roles in normal and...

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PMID: 24124521
DOI: 10.1371/journal.pone.0075907

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