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Article

EGR1 and the ERK‐ERF axis drive mammary cell migration in response to EGF

23 Dec 2011

Abstract excerpt

The signaling pathways that commit cells to migration are incompletely understood. We employed human mammary cells and two stimuli: epidermal growth factor (EGF), which induced cellular migration, and serum factors, which stimulated cell growth. In addition to strong activation of ERK by EGF, and AKT by serum, early transcription remarkably differed: while EGF induced early growth response‐1 (EGR1), and this was...

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PMID: 22198386
DOI: 10.1096/fj.11-194654

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