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Article

The adaptor protein AMOT promotes the proliferation of mammary epithelial cells via the prolonged activation of the extracellular signal-regulated kinases.

Cancer research - 15 Mar 2011

Ranahan William P, Han Zhang, Smith-Kinnaman Whitney, Nabinger Sarah C, Heller Brigitte, Herbert Britney-Shea, Chan Rebecca, Wells Clark D

Abstract excerpt

The asymmetric organization of epithelial cells is a basic counter to cellular proliferation. However, the mechanisms whereby pro-growth pathways are modulated by intracellular factors that control cell shape are not well understood. This study demonstrates that the adaptor protein Amot, in addition to its established role in regulating cellular asymmetry, also promotes extracellular signal-regulated kinase 1 and...

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Source

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Identifiers

PMID: 21285250
DOI: 10.1158/0008-5472.CAN-10-1995
PMCID: PMC3996846

Genes

AMOT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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