Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.

Journal of cellular physiology - 1 Oct 2011

Baillo Andrea, Giroux Craig, Ethier Stephen P

Abstract excerpt

We have previously shown that SUM-149 human breast cancer cells require an amphiregulin (AREG) autocrine loop for cell proliferation. We also demonstrated that AREG can increase epidermal growth factor receptor (EGFR) stability and promote EGFR localization to the plasma membrane. In the present studies we successfully knocked-down AREG expression in SUM-149 cells by lentiviral infection of AREG shRNA. In the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to ErbB Receptors
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Glycoproteins

Share to Intercellular Signaling Peptides and Proteins

Share to Neoplasm Invasiveness

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 21302279
DOI: 10.1002/jcp.22620
PMCID: PMC3865809

Genes

AREG
EGFR
DKK1
RHOB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knock-down of amphiregulin inhibits cellular invasion in inflammatory breast cancer.PMID 21302279Read ↗

A functional screen for genes inducing epidermal growth factor autonomy of human mammary epithelial cells confirms the role of amphiregulin.Semantic proximity Read ↗

Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.Semantic proximity Read ↗

Amphoterin as an extracellular regulator of cell motility: from discovery to diseaseSemantic proximity Read ↗

Antisense expression for amphiregulin suppresses tumorigenicity of a transformed human breast epithelial cell line.Semantic proximity Read ↗

RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype.Semantic proximity Read ↗

Transgenic expression of human amphiregulin in mouse skin: inflammatory epidermal hyperplasia and enlarged sebaceous glands.Semantic proximity Read ↗

Anoikis resistance in mammary epithelial cells is mediated by semaphorin 7a.Semantic proximity Read ↗

Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.Semantic proximity Read ↗

Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancerSemantic proximity Read ↗

EZH2 knockdown suppresses the growth and invasion of human inflammatory breast cancer cellsSemantic proximity Read ↗

Amphiregulin confers trastuzumab resistance via AKT and ERK activation in HER2-positive breast cancer.Semantic proximity Read ↗

Inflammatory breast cancer: relationship between growth factor signaling and motility in aggressive cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.