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Article

Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells.

PloS one - 1 Jan 2019

Osada Asami Hotta, Endo Kaori, Kimura Yujiro, Sakamoto Kei, Nakamura Ryosuke, Sakamoto Kaname, Ueki Koichiro, Yoshizawa Kunio, Miyazawa Keiji, Saitoh Masao

Abstract excerpt

The epithelial-mesenchymal transition (EMT) is a crucial morphological event that occurs during epithelial tumor progression. ZEB1/2 are EMT transcription factors that are positively correlated with EMT phenotypes and breast cancer aggressiveness. ZEB1/2 regulate the alternative splicing and hence isoform switching of fibroblast growth factor receptors (FGFRs) by repressing the epithelial splicing regulatory...

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Source

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Identifiers

PMID: 31682640
DOI: 10.1371/journal.pone.0217451
PMCID: PMC6827898

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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