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Article

Lgr5-expressing chief cells drive epithelial regeneration and cancer in the oxyntic stomach.

Nature cell biology - 1 Jul 2017

Leushacke Marc, Tan Si Hui, Wong Angeline, Swathi Yada, Hajamohideen Amin, Tan Liang Thing, Goh Jasmine, Wong Esther, Denil Simon L I J, Murakami Kazuhiro, Barker Nick

Abstract excerpt

The daily renewal of the corpus epithelium is fuelled by adult stem cells residing within tubular glands, but the identity of these stem cells remains controversial. Lgr5 marks homeostatic stem cells and 'reserve' stem cells in multiple tissues. Here, we report Lgr5 expression in a subpopulation of chief cells in mouse and human corpus glands. Using a non-variegated Lgr5-2A-CreERT2 mouse model, we show by lineage...

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PMID: 28581476
DOI: 10.1038/ncb3541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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