Article

Wnt/PCP-primed intestinal stem cells directly differentiate into enteroendocrine or Paneth cells

2020-08-12

Abstract excerpt

<h4>SUMMARY</h4> A detailed understanding of intestinal stem cell (ISC) self-renewal and differentiation is required to better treat chronic intestinal diseases. However, different models of ISC lineage hierarchy 1–6 and segregation 7–12 are debated. Here we report the identification of Lgr5 + ISCs that express Flattop ( Fltp ), a Wnt/planar cell polarity (PCP) reporter and effector gene. Lineage labelling r...

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Literature Corpus work: f7df90a3-b436-57cd-82a8-dce02c818652
DOI: 10.1101/2020.08.12.247585

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