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Article

Lgr4 is required for Paneth cell differentiation and maintenance of intestinal stem cells ex vivo.

EMBO reports - 1 Jun 2011

Mustata Roxana C, Van Loy Tom, Lefort Anne, Libert Frédérick, Strollo Sandra, Vassart Gilbert, Garcia Marie-Isabelle

Abstract excerpt

Gene inactivation of the orphan G protein-coupled receptor LGR4, a paralogue of the epithelial-stem-cell marker LGR5, results in a 50% decrease in epithelial cell proliferation and an 80% reduction in terminal differentiation of Paneth cells in postnatal mouse intestinal crypts. When cultured ex vivo, LGR4-deficient crypts or progenitors, but not LGR5-deficient progenitors, die rapidly with marked downregulation...

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Identifiers

PMID: 21508962
DOI: 10.1038/embor.2011.52
PMCID: PMC3128273

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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