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Article

Single-cell analysis of proxy reporter allele-marked epithelial cells establishes intestinal stem cell hierarchy.

Stem cell reports - 11 Nov 2014

Li Ning, Yousefi Maryam, Nakauka-Ddamba Angela, Jain Rajan, Tobias John, Epstein Jonathan A, Jensen Shane T, Lengner Christopher J

Abstract excerpt

The recent development of targeted murine reporter alleles as proxies for intestinal stem cell activity has led to significant advances in our understanding of somatic stem cell hierarchies and dynamics. Analysis of these reporters has led to a model in which an indispensable reserve stem cell at the top of the hierarchy (marked by Bmi1 and Hopx reporters) gives rise to active intestinal stem cells (marked by an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25418730
DOI: 10.1016/j.stemcr.2014.09.011
PMCID: PMC4235148

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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