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Article

Robust cre-mediated recombination in small intestinal stem cells utilizing the olfm4 locus.

Stem cell reports - 12 Aug 2014

Schuijers Jurian, van der Flier Laurens G, van Es Johan, Clevers Hans

Abstract excerpt

The epithelium of the small intestine is the most rapidly self-renewing tissue in mammals. We previously demonstrated the existence of a long-lived pool of cycling stem cells defined by Lgr5 expression at the bottom of intestinal crypts. An Lgr5-eGFP-IRES-CreERT2 knockin allele has been instrumental in characterizing and profiling these cells, yet its low level expression and its silencing in patches of adjacent...

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Identifiers

PMID: 25254337
DOI: 10.1016/j.stemcr.2014.05.018
PMCID: PMC4175542

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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