Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory.

doi:10.1038/npp.2016.14

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Article

Prefrontal White Matter Structure Mediates the Influence of GAD1 on Working Memory.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Aug 2016

Lett Tristram A, Kennedy James L, Radhu Natasha, Dominguez Luis G, Chakravarty M Mallar, Nazeri Arash, Farzan Faranak, Walter Henrik, Heinz Andreas, Mulsant Benoit H, Daskalakis Zafiris J, Voineskos Aristotle N

Abstract excerpt

The glutamic acid decarboxylase 1 (GAD1) gene is a major determinant of γ-aminobutyric acid (GABA), the most abundant inhibitory neurotransmitter modulating local neuronal circuitry. GABAergic dysfunction and expression of GAD1 have been implicated in the pathophysiology of schizophrenia, and in working memory impairment. We examined the influence of the functional GAD1 rs3749034 variant on white matter...

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Identifiers

PMID: 26822489
DOI: 10.1038/npp.2016.14
PMCID: PMC4946050

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GAD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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