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Article

The COMT Val158Met polymorphism moderates the association between cognitive functions and white matter microstructure in schizophrenia.

Psychiatric genetics - 1 Oct 2016

Poletti Sara, Mazza Elena, Bollettini Irene, Falini Andrea, Smeraldi Enrico, Cavallaro Roberto, Benedetti Francesco

Abstract excerpt

OBJECTIVES: Impaired cognitive functioning is a core feature of schizophrenia. Cognitive impairment in schizophrenia has been associated with white-matter (WM) abnormalities and degenerative changes of cortical myelin in the cerebral cortex. Furthermore, findings suggested a role of the COMT gene in affecting both WM and neuropsychological performances.We thus hypothesized that the COMT ValMet genotype would...

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Share to Catechol O-Methyltransferase
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26999687
DOI: 10.1097/YPG.0000000000000130

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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