Article
Effect of glutamate transporter EAAT2 gene variants and gray matter deficits on working memory in schizophrenia.
European psychiatry : the journal of the Association of European Psychiatrists - 1 May 2014
Poletti S, Radaelli D, Bosia M, Buonocore M, Pirovano A, Lorenzi C, Cavallaro R, Smeraldi E, Benedetti F
Abstract excerpt
Glutamate is the major excitatory neurotransmitter in the brain, with up to 40% of all synapses being glutamatergic. An altered glutamatergic transmission could play a critical role in working memory deficts observed in schizophrenia and could underline progressive changes such as grey matter loss throughout the brain. The aim of the study was to investigate if gray matter volume and working memory could be...
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