Article

Network-based Molecular Constraints on in vivo Synaptic Density Alterations in Schizophrenia

2025-03-23

Abstract excerpt

Converging neuroimaging, genetic, and post-mortem evidence highlights the fundamental role of synaptic density reductions in schizophrenia pathogenesis. However, the brain-wide spatial pattern of these alterations and the mechanisms underlying this patterning remain to be established. Here, using [11C]UCB-J radiotracer positron emission tomography (PET) imaging in individuals with schizophrenia (n=29) and healthy...

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Literature Corpus work: 573ec6f1-76b4-52de-ab9d-e0aea568c6a5
DOI: 10.1101/2025.03.22.25324465

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