Article
Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2010
Marenco Stefano, Savostyanova Antonina A, van der Veen Jan Willem, Geramita Matthew, Stern Alexa, Barnett Alan S, Kolachana Bhaskar, Radulescu Eugenia, Zhang Fengyu, Callicott Joseph H, Straub Richard E, Shen Jun, Weinberger Daniel R
Abstract excerpt
Gamma-aminobutyric acid (GABA)-ergic transmission is critical for normal cortical function and is likely abnormal in a variety of neuropsychiatric disorders. We tested the in vivo effects of variations in two genes implicated in GABA function on GABA concentrations in prefrontal cortex of living subjects: glutamic acid decarboxylase 1 (GAD1), which encodes GAD67, and catechol-o-methyltransferase (COMT), which...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.