Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression.

doi:10.1038/sj.mp.4001988

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Article

Allelic variation in GAD1 (GAD67) is associated with schizophrenia and influences cortical function and gene expression.

Molecular psychiatry - 1 Sept 2007

Straub R E, Lipska B K, Egan M F, Goldberg T E, Callicott J H, Mayhew M B, Vakkalanka R K, Kolachana B S, Kleinman J E, Weinberger D R

Abstract excerpt

Cortical GABAergic dysfunction has been implicated as a key component of the pathophysiology of schizophrenia and decreased expression of the gamma-aminobutyric acid (GABA) synthetic enzyme glutamic acid decarboxylase 67 (GAD(67)), encoded by GAD1, is found in schizophrenic post-mortem brain. We report evidence of distorted transmission of single-nucleotide polymorphism (SNP) alleles in two independent...

Topics

Adolescent
Adult
Alleles
Catechol O-Methyltransferase
Cerebral Cortex
Family Health
Female
Gene Expression
Gene Frequency
Genetic Predisposition to Disease
Glutamate Decarboxylase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Image Processing, Computer-Assisted

Linkage Disequilibrium

Magnetic Resonance Imaging

Male

Middle Aged

Neuropsychological Tests

Source

Open in PubMed

Identifiers

PMID: 17767149
DOI: 10.1038/sj.mp.4001988

Genes

GAD1
COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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