Article
The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function.
PloS one - 1 Jan 2013
Walton Esther, Geisler Daniel, Hass Johanna, Liu Jingyu, Turner Jessica, Yendiki Anastasia, Smolka Michael N, Ho Beng-Choon, Manoach Dara S, Gollub Randy L, Roessner Veit, Calhoun Vince D, Ehrlich Stefan
Abstract excerpt
The neural mechanisms underlying genetic risk for schizophrenia, a highly heritable psychiatric condition, are still under investigation. New schizophrenia risk genes discovered through genome-wide association studies (GWAS), such as neurogranin (NRGN), can be used to identify these mechanisms. In this study we examined the association of two common NRGN risk single nucleotide polymorphisms (SNPs) with functional...
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