Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.

Genes and immunity - 1 Mar 2016

Gall B J, Wilson A, Schroer A B, Gross J D, Stoilov P, Setola V, Watkins C M, Siderovski D P

Abstract excerpt

G protein signaling modulator 3 (GPSM3) is a regulator of G protein-coupled receptor signaling, with expression restricted to leukocytes and lymphoid organs. Previous genome-wide association studies have highlighted single-nucleotide polymorphisms (SNPs; rs204989 and rs204991) in a region upstream of the GPSM3 transcription start site as being inversely correlated to the prevalence of rheumatoid arthritis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Arthritis, Rheumatoid

Share to Chemokine CCL2

Share to Chemotaxis

Share to Gene Expression

Share to Guanine Nucleotide Dissociation Inhibitors

Share to Homozygote

Share to Monocytes

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 26821282
DOI: 10.1038/gene.2016.3
PMCID: PMC4777669

Genes

GPSM3
CCL21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variations in GPSM3 associated with protection from rheumatoid arthritis affect its transcript abundance.PMID 26821282Read ↗

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.Semantic proximity Read ↗

LncRNA MEG3 as a biomarker and therapeutic target in rheumatoid arthritis: Insights from gene polymorphisms, expression patterns, and functional mechanisms.Semantic proximity Read ↗

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.Semantic proximity Read ↗

ORMDL3 and its implication in inflammatory disorders.Semantic proximity Read ↗

Juvenile idiopathic arthritis associated with a mutation in GATA3.Semantic proximity Read ↗

The genetic association of RUNX3 with ankylosing spondylitis can be explained by allele-specific effects on IRF4 recruitment that alter gene expression.Semantic proximity Read ↗

Race-specific association of an IRGM risk allele with cytokine expression in human subjects.Semantic proximity Read ↗

Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.Semantic proximity Read ↗

Disruption of c-MYC Binding and Chromosomal Looping Involving Genetic Variants Associated With Ankylosing Spondylitis Upstream of the RUNX3 PromoterSemantic proximity Read ↗

Importance of STAT3 Polymorphisms on the Risk and Clinical Characteristics of Rheumatoid Arthritis.Semantic proximity Read ↗

Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population.Semantic proximity Read ↗

STAT3 locus in inflammatory bowel disease and multiple sclerosis susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.