Article
Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.
Cell - 26 Sept 2013
Lee James C, Espéli Marion, Anderson Carl A, Linterman Michelle A, Pocock Joanna M, Williams Naomi J, Roberts Rebecca, Viatte Sebastien, Fu Bo, Peshu Norbert, Hien Tran Tinh, Phu Nguyen Hoan, Wesley Emma, Edwards Cathryn, Ahmad Tariq, Mansfield John C, Gearry Richard, Dunstan Sarah, Williams Thomas N, Barton Anne, Vinuesa Carola G, Parkes Miles, Lyons Paul A, Smith Kenneth G C
Abstract excerpt
The clinical course and eventual outcome, or prognosis, of complex diseases varies enormously between affected individuals. This variability critically determines the impact a disease has on a patient's life but is very poorly understood. Here, we exploit existing genome-wide association study data to gain insight into the role of genetics in prognosis. We identify a noncoding polymorphism in FOXO3A (rs12212067:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.