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Article

Reduction of GPSM3 expression akin to the arthritis-protective SNP rs204989 differentially affects migration in a neutrophil model.

Genes and immunity - 1 Sept 2016

Gall B J, Schroer A B, Gross J D, Setola V, Siderovski D P

Abstract excerpt

G Protein Signaling Modulator-3 (GPSM3) is a leukocyte-specific regulator of G protein-coupled receptors (GPCRs), which binds inactivated Gαi·GDP subunits and precludes their reassociation with Gβγ subunits. GPSM3 deficiency protects mice from inflammatory arthritis and, in humans, GPSM3 single-nucleotide polymorphisms (SNPs) are inversely associated with the risk of rheumatoid arthritis development; recently,...

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Share to Arthritis, Rheumatoid
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemotaxis, Leukocyte

Share to Guanine Nucleotide Dissociation Inhibitors

Share to Interleukin-8

Share to Neutrophils

Share to Polymorphism, Single Nucleotide

Share to Tretinoin

Source

Open in PubMed Open full text

Identifiers

PMID: 27307211
DOI: 10.1038/gene.2016.26
PMCID: PMC5009006

Genes

GPSM3
CXCL8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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